Depletion and Replenishment of Vesicle Pools at a Ribbon-Type Synaptic Terminal
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چکیده
منابع مشابه
Depletion and replenishment of vesicle pools at a ribbon-type synaptic terminal.
Synaptic depression was studied using capacitance measurements in synaptic terminals of retinal bipolar neurons. Single 250 msec depolarizations evoked saturating capacitance responses averaging approximately 150 fF, whereas trains of 250 msec depolarizations produced plateau capacitance increases of approximately 300 fF. Both types of stimuli were followed by pronounced synaptic depression, wh...
متن کاملVesicle depletion and synaptic depression at a mammalian ribbon synapse.
We estimated the size of the readily releasable pool (RRP) of vesicles at a ribbon synapse in the rat retina by making paired voltage-clamp recordings from presynaptic rod bipolar cells (RBCs) and postsynaptic AII amacrine cells in an in vitro retinal slice preparation. The RRP at each active zone was estimated to constitute seven vesicles, in the range of estimated RRP sizes at conventional sy...
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Cones release glutamate-filled vesicles continuously in darkness, and changing illumination modulates this release. Because sustained release in darkness is governed by vesicle replenishment rates, we analyzed how cone membrane potential regulates replenishment. Synaptic release from cones was measured by recording postsynaptic currents in Ambystoma tigrinum horizontal or OFF bipolar cells evok...
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Cerebellar basket cells inhibit postsynaptic Purkinje cells in a rapid and precise manner. To investigate the mechanisms of transmitter release underlying this rapid inhibition, Ca(2+) uncaging was employed to measure the intracellular Ca(2+) dependence of transmitter release and the kinetics of synaptic vesicle pool transitions in immature basket cell synapses at room temperature. Vesicle rele...
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Synaptic vesicles release neurotransmitter at chemical synapses, thus initiating the flow of information in neural networks. To achieve this, vesicles undergo a dynamic cycle of fusion and retrieval to maintain the structural and functional integrity of the presynaptic terminals in which they reside. Moreover, compelling evidence indicates these vesicles differ in their availability for release...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1997
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.17-06-01919.1997